Infectious agents are associated with 20% of cancers worldwide. Several human oncogenic viruses, such as Epstein-Barr virus (EBV), are endemic but only a small portion of individuals develop cancer, often even decades after infection.

Malignant transformation thus requires multiple additional oncogenic hits, including host and environmental co-factors.

In the viral oncogenesis lab we want to determine at the molecular level the role of the oncogenic hits for understanding the principles of viral-induced cancers and for developing targeted therapies